BCL11B, the Cerberus of human leukemia

Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells

Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T cell leukemia (ATL), which is an aggressive form of T-cell malignancy. HTLV-1 oncoproteins, Tax and HBZ, play crucial roles in the immortalization of T-cells and/or leukemogenesis by dysregulating the cellular functions in the host. Recent studies show that HTLV-1-infected T-cells have reduced expression of the BCL1...

Reduced Level of the BCL11B Protein Is Associated with Adult T-Cell Leukemia/Lymphoma

BACKGROUND Adult T-cell leukemia/lymphoma (ATLL) develops in a small proportion of human T-cell leukemia virus type I (HTLV-I)-infected individuals. However, the mechanism by which HTLV-I causes ATLL has not been fully elucidated. To provide fundamental insights into the multistep process of leukemogenesis, we have mapped the chromosomal abnormalities in 50 ATLL cases to identify potential key ...

Cerberus’05 Team Report

Investigations into the Cerberus Outflow Channels, Mars

Mars Orbiter Camera (MOC) images and Mars Orbiter Laser Altimeter (MOLA) data on the Mars Global Surveyor (MGS) spacecraft show evidence for three catastrophic outflow channels around the Cerberus Plains region, Mars. The morphologies seen in MOC images located within channels seen in gridded MOLA topography are similar to those found in catastrophic flood terrains on Earth, such as the Channel...

The role of BCL11B in hematological malignancy

The B-cell leukemia/lymphoma 11B (BCL11B) gene is a member of the BCL family which plays a crucial role in the development, proliferation, differentiation and subsequent survival of T cells. BCL11B gene alterations are related to malignant T cell transformation that occurs in hematological malignancies. Remarkably, the BCL11B gene is responsible for the regulation of the apoptotic process and c...